The ectoparasitic honey bee mite, Varrroa destructor, was originally affecting the partially resistant Asian honeybee Apis cerana, until a host shift happened to the European honeybee, Apis mellifera. During last three decades this mite became present world-wide, heavily affecting honeybee populations, honey production and beekeeping in several countries around the world. Unfortunately, no permanent solution has been found to this, emerging this parasitic mite as the foremost problem for apiculture worldwide. In addition, research in the biology, behavior and life cycle of V. destructor has been almost solely conducted on the western honeybee. Nonetheless, a deeper understanding of the original host-parasite relationship would help to better comprehend the current host-parasite association. In this research three different aspects of the interaction between V. destructor and Apis spp. will be investigated. Firstly, we will focus our attention on the mechanisms involved in the Varroa dispersion through different colonies, in particular on the phenomenon of robbing that takes place usually during late summer. A second section will aim to study the interspecific co-adaptation between Varroa and the original host, A. cerana, by looking at the chemo-ecological interaction between these two species. The last part of this study will be orientated to investigate the feasibility of biological control agents against V. destructor in mountain environment. Principally, the efforts will be concentrated on the entomo-pathogenic fungus Metarhizium anisopliae. In a long term this research would provide valuable information about the interaction between V. destructor and honeybees from the chemical-ecology perspective as possible advances in biological control.